The Centre for Area Studies, founded in 2009, is an interdisciplinary and interdepartmental research institute at the Faculty of Social Sciences and Philosophy of the University of Leipzig. Placing a special emphasis on the academic collaboration between area studies and other disciplines in social sciences and humanities, CAS facilitates transregional and global approaches. The successful realization of the research programme “Cultural Encounters and Political Orders in a Global Age” during the first funding period (2009–2014) propelled the establishment of these approaches in bachelor’s, master’s, and PhD programmes as well as the internationalization strategies of the university. The second research phase 2014–2016 aimed to systematically summarize the individual research projects of the first funding period and future work on guiding categories for a historically grounded globalization research. The fruit of these efforts will be a two-volume Handbook on Transregional Studies comprised of contributions from a wide spectrum of international scholars.